Concerned about keyword stuffing with location based keywords

So lets say I am trying to target Boston breweries as a keyword. However, I also want to target things like "Boston beer brewers," "Boston IPA," "Boston bars" as my other keywords. Naturally, I'll be saying Boston often in the copy on my homepage. I'm concerned if I write Boston too many times, it'll see that either as stuffing worst-case or nullify it as a keyword, best case.

Are my concerns misplaced? What's the best practice for this?